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Related Concept Videos

The Parathyroid Glands00:59

The Parathyroid Glands

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The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
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Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

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Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH...
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Hyperthyroidism I: Introduction01:25

Hyperthyroidism I: Introduction

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Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...
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The Thyroid Gland01:23

The Thyroid Gland

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The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
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Related Experiment Video

Updated: Apr 27, 2026

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging
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Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging

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Functioning oxyphil parathyroid adenoma: a case report.

Rajendra B Metgudmath1, Vinita V Metgudmath2, Prakash R Malur3

  • 1Associate Professor, Department of Otorhinolaryngology, Head and Neck Surgery, Jawaharlal Nehru Medical College, KLE University , Belgaum, Karnataka, India .

Journal of Clinical and Diagnostic Research : JCDR
|June 25, 2014
PubMed
Summary
This summary is machine-generated.

Oxyphil adenomas, a rare cause of primary hyperparathyroidism, present unique clinical features. This case highlights their distinct presentation and successful surgical management.

Keywords:
HyperparathyroidismOxyphilic adenomaParathyroidectomy

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Area of Science:

  • Endocrinology
  • Surgical Pathology
  • Oncology

Background:

  • Oxyphil parathyroid adenomas are uncommon, with poorly defined clinical characteristics.
  • Primary hyperparathyroidism necessitates understanding diverse etiological factors.

Observation:

  • A patient presented with primary hyperparathyroidism, significantly elevated parathyroid hormone (PTH), and near-normal calcium levels.
  • Surgical intervention (parathyroidectomy) was performed for the condition.

Findings:

  • Histopathology confirmed an oxyphil adenoma with positive PTH staining via immunohistochemistry.
  • Post-surgery, significant reductions in PTH and alkaline phosphatase were observed.

Implications:

  • Benign oxyphil adenomas can resemble parathyroid carcinomas clinically and by size.
  • These tumors must be considered in the differential diagnosis of primary hyperparathyroidism.