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A Protocol for Analyzing Hepatitis C Virus Replication
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A Protocol for Analyzing Hepatitis C Virus Replication

Published on: June 26, 2014

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Hepatitis C virus infection and dialysis: 2012 update

Fabrizio Fabrizi1

  • 1Division of Nephrology and Dialysis, Maggiore Hospital and IRCCS Foundation, Padiglione Croff, Via Commenda 15, 20122 Milan, Italy.

ISRN Nephrology
|June 25, 2014
PubMed

Insights

Hepatitis C virus (HCV) infection in dialysis patients is linked to significantly higher mortality from liver and cardiovascular diseases. Treatment decisions should weigh risks and benefits, with modern antiviral therapies showing promise.

Area of Science:

  • Nephrology
  • Hepatology
  • Infectious Diseases

Background:

  • Hepatitis C virus (HCV) infection remains prevalent in dialysis patients, yet its long-term impact on survival is not fully understood.
  • Anti-HCV positive serologic status is associated with increased liver and cardiovascular disease-related mortality in this population.

Purpose of the Study:

  • To evaluate the mortality risks associated with HCV infection in dialysis patients.
  • To assess the efficacy and outcomes of antiviral therapies for HCV in patients undergoing dialysis.

Main Methods:

  • A meta-analysis of fourteen studies involving 145,608 unique patients was conducted to determine the adjusted relative risk (RR) for liver disease-related and cardiovascular mortality.
  • A pooled analysis of 151 dialysis patients examined sustained viral response and dropout rates for combination antiviral therapy.

Main Results:

  • The adjusted RR for liver disease-related death was 3.82 (95% CI, 1.92; 7.61) and for cardiovascular mortality was 1.26 (95% CI, 1.10; 1.45) in anti-HCV positive patients.
  • Combination antiviral therapy (pegylated interferon plus ribavirin) demonstrated a 56% sustained viral response rate, with a 25% dropout rate.

Conclusions:

  • HCV infection significantly increases mortality risk in dialysis patients, underscoring the need for careful treatment considerations.
  • Modern antiviral therapies, such as pegylated interferon plus ribavirin, offer a viable treatment option with a notable sustained viral response rate.

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