Related Experiment Video
Updated: Apr 27, 2026

Investigating Migraine-Like Behavior Using Light Aversion in Mice
Published on: August 11, 2021
Effects of tumor necrosis factor-β (TNF-β) 252A>G polymorphism on the development of migraine: a meta-analysis
Ruozhuo Liu1, Minghui Ma2, Mingyu Cui1
1Department of Neurology, Chinese PLA General Hospital, Beijing, China.
Background And Objective:
Genetic factors including TNF-β have been considered as important components in the aetiology of migraine. Many studies have investigated the association between TNF-β 252A>G polymorphism and migraine risk, with debatable results. This study was designed to examine whether the TNF-β 252A>G polymorphism confers genetic susceptibility to migraine in diverse populations.
Method:
Studies eligible for this meta-analysis were searched in the PubMed, Embase, and CNKI by using the keywords "tumor necrosis factor", "TNF", "252A>G", "rs909253", "polymorphism", "polymorphisms", "variant", "SNP", combined with "migraine" or "migraine with aura (MA)" or "migraine without aura (MO)". Pooled ORs and 95% CI were appropriately calculated using the fixed-effect model.
Results:
We finally included a total of seven studies, providing 5 557 migraineurs and 20 543 unrelated healthy controls. Meta-analysis results showed no statistical evidence of a significant association between TNF-β 252A>G polymorphism and overall migraine risk. Stratified analyses by type of migraine and gender revealed similar results. Interestingly, an OR with 95% CI representing an increased migraine risk was indicated in Asians under the recessive model (GG vs. AG + AA: OR, 1.38; 95%CI, 1.04-1.84; P for heterogeneity, 0.665).
Conclusions:
Our findings appear to support the hypothesis that genetic variability of 252A>G polymorphism in TNF region may modulate risk of migraine in the population of Asian ancestry.
Related Concept Videos
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
NF-κB-dependent Signaling Pathway
NF-κB-dependent Signaling Mechanism
The...
Pharmacogenetics of Phase II Enzymes: N-acetyltransferase, Thiopurine S-methyltransferase, UDP-glucuronosyltransferase
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

