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α-Synuclein-induced membrane remodeling is driven by binding affinity, partition depth, and interleaflet order

Anthony R Braun1, Michael M Lacy, Vanessa C Ducas

  • 1Department of Biomedical Engineering, University of Minnesota , Minneapolis, Minnesota 55455, United States.

Journal of the American Chemical Society
|June 25, 2014
PubMed
Summary

The N-terminal domain of alpha-synuclein (α-Syn100) tubulates pure lipid vesicles, but not mixed ones. This membrane remodeling is crucial for understanding protein-lipid interactions.

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