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Related Experiment Videos

Ethane production rates and minute ventilation.

M P Habib1, M A Katz

  • 1Benjamin W. Zweifach Microcirculation Laboratories, Tucson Veterans Administration Medical Center, Arizona.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|March 1, 1989
PubMed
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Ethane elimination rates, a measure of free radical activity, are not affected by changes in minute ventilation (VE) or pentobarbital anesthesia. This validates ethane as a reliable noninvasive biomarker in animal studies.

Area of Science:

  • Biomedical Science
  • Physiology
  • Biomarker Research

Background:

  • Ethane in expired gas is a noninvasive marker for free radical activity.
  • Concerns exist regarding the influence of minute ventilation (VE) on ethane measurements in spontaneously breathing animals.

Purpose of the Study:

  • To investigate the impact of varying minute ventilation (VE) on ethane elimination rates.
  • To determine if pentobarbital anesthesia affects ethane elimination measurements.

Main Methods:

  • Ethane elimination rates were measured in spontaneously breathing and mechanically ventilated guinea pigs (GP13).
  • Minute ventilation (VE) was controlled in anesthetized, tracheostomized animals.
  • Arterial CO2 tension (PaCO2) was monitored in ventilated subjects.

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Main Results:

  • Ethane elimination rates were not significantly different between spontaneously breathing and mechanically ventilated guinea pigs.
  • No correlation was found between metabolic activity corrected for VE and ethane elimination rates.
  • Pentobarbital anesthesia did not affect ethane elimination rates.

Conclusions:

  • Ethane elimination rates are independent of changes in minute ventilation (VE).
  • Pentobarbital anesthesia does not alter ethane elimination measurements.
  • Ethane is a reliable noninvasive biomarker for free radical activity, unaffected by VE or anesthesia.