Related Experiment Video
Updated: Apr 27, 2026

Wheel Running and Environmental Complexity as a Therapeutic Intervention in an Animal Model of FASD
Published on: February 2, 2017
On aerobic exercise and behavioral and neural plasticity
Rodney A Swain1, Kiersten L Berggren2, Abigail L Kerr3
1Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, WI 53211, USA. rswain@uwm.edu.
Aerobic exercise significantly alters brain function, impacting mood, cognition, and behavior. These brain changes, including neurogenesis and synaptogenesis, offer therapeutic potential for aging and cognitive decline.
Area of Science:
- Neuroscience
- Exercise Physiology
- Behavioral Psychology
Background:
- Aerobic exercise induces significant brain alterations beyond motor control.
- These changes affect neural regions associated with learning, cognition, and emotion.
- Exercise impacts brain plasticity, mood, and behavior.
Purpose of the Study:
- To explore psychological and psychobiological literature on exercise and brain effects.
- To link neural plasticity changes to behavior and emotional expression.
- To investigate exercise's therapeutic potential in neuroprotection and cognitive aging.
Main Methods:
- Review of psychological and psychobiological research.
- Analysis of studies in human and non-human animals.
- Examination of exercise-induced changes in brain structure and function.
Main Results:
- Exercise influences brain blood flow, hormone release, and receptor expression.
- Key processes like angiogenesis, neurogenesis, and synaptogenesis are affected.
- Observed mood elevation and behavioral plasticity correlate with chronic exercise.
Conclusions:
- Exercise-induced brain alterations underlie mood and behavioral changes.
- Aerobic exercise shows potential as a neuroprotectant.
- Exercise may slow cognitive decline in normal and pathological aging.
Related Concept Videos
Neuroplasticity
Exercise and Muscle Performance
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
Exercise and Cardiac Output
Sustained exercise increases the muscles' oxygen demand, which can be...
Exercise and Cardiovascular Response
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Long-term Potentiation
Long-term Potentiation
Hebbian LTP
LTP can occur when...

