Neuroimaging studies of sleep and memory in humans

Human brain dynamics are nowadays routinely explored at the macroscopic level using a wide variety of non-invasive neuroimaging techniques, including single photon emission computed tomography (SPECT) and positron emission tomography (PET), near infrared spectroscopy (NIRS) and functional magnetic resonance imaging (fMRI). In the past decades, the application of brain imaging methods to the study of sleep raised a renewed interest for the field, especially in the domain of neuroscience. Indeed, these studies enabled researchers to characterize the functional neuroanatomy of sleep stages and identify the neural correlates of phasic and tonic sleep mechanisms. Furthermore, they provided the scientific community with tools to address the crucial question of brain plasticity processes during human sleep, the role of sleep-related plasticity for memory consolidation, and how sleep and the lack of post-training sleep impacts brain functioning in the neural networks underlying memory-related cognitive processes. This chapter reviews the contributions of neuroimaging to our understanding of the functional neuroanatomy of sleep and sleep stages, and discusses how sleep contributes to the long-term consolidation of recently acquired memories in light of contemporary neural models for memory consolidation during sleep.