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Manipulation of biological objects using acoustic bubbles: a review.
1Department of Mechanical Engineering, Texas A&M, College Station, TX 77843, USA chen82@neo.tamu.edu.
Integrative and Comparative Biology
|June 26, 2014
Summary
Acoustically driven oscillating bubbles create forces that manipulate micro-objects. This review explores the physics and biological applications of oscillating bubbles for controlling microorganisms and cells.
Area of Science:
- Acoustic physics
- Biophysics
- Microfluidics
Background:
- Oscillating bubbles generate forces on nearby micro-objects.
- Acoustic streaming from bubbles causes viscous drag.
- These phenomena are utilized for micro-object manipulation in biological contexts.
Purpose of the Study:
- To explain the physical mechanisms of oscillating bubbles.
- To review key biological applications of oscillating bubbles.
- To focus on the manipulation of microorganisms and cells.
Main Methods:
- Review of physical principles governing bubble oscillations.
- Analysis of forces acting on micro-objects (acoustic radiation force, viscous drag).
- Compilation and discussion of existing biological applications.
Main Results:
- Oscillating bubbles exert attractive forces on micro-objects.
- Acoustic streaming generates drag forces influencing micro-object movement.
- Successful manipulation of microorganisms (e.g., Caenorhabditis elegans, Daphnia) and cells has been demonstrated.
Conclusions:
- Oscillating bubbles offer a non-invasive method for micro-object manipulation.
- Applications include controlling live microorganisms, cells, and drug/gene delivery.
- Further research can expand the use of oscillating bubbles in biology and medicine.
