Related Experiment Video
Updated: Apr 27, 2026

A Method to Define the Effects of Environmental Enrichment on Colon Microbiome Biodiversity in a Mouse Colon Tumor Model
Published on: February 28, 2018
Functional divergence in gastrointestinal microbiota in physically-separated genetically identical mice
G B Rogers1, J Kozlowska2, J Keeble2
11] Immunity, Infection, and Inflammation Program, Mater Research Institute - University of Queensland, Translational Research Institute, Woolloongabba, Australia [2] King's College London, Institute of Pharmaceutical Science, London, SE1 9NH, UK [3] SAHMRI Infection and Immunity Theme, School of Medicine, Flinders University, Bedford Park, Adelaide, Australia.
Abstract:
Despite the fundamental contribution of the gut microbiota to host physiology, the extent of its variation in genetically-identical animals used in research is not known. We report significant divergence in both the composition and metabolism of gut microbiota in genetically-identical adult C57BL/6 mice housed in separate controlled units within a single commercial production facility. The reported divergence in gut microbiota has the potential to confound experimental studies using mammalian models.
More Related Videos
05:28Analysis of Fecal Microbiota Dynamics in Lupus-Prone Mice Using a Simple, Cost-Effective DNA Isolation Method
Published on: May 2, 2022
07:45Preparation and Maintenance of Bioexclusion IsoPositive Cage Experiment for Human Fecal Transplantation into Germ-Free Mice
Published on: February 28, 2025
Related Concept Videos
Microbiota of the Stomach and Small Intestine
Microbiota of the Large Intestine
Development of Human Microbiota
Evolution of Microbial Genome
Introduction to the Human Microbiota