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Related Concept Videos

Degenerative Disc Disease I: Introduction01:27

Degenerative Disc Disease I: Introduction

26
Degenerative disc disease is a chronic condition in which intervertebral discs gradually lose structure and function. It is not infectious or autoimmune; rather, it results from age-related biochemical and mechanical changes, influenced by genetic, metabolic, and environmental factors.Structure and Function of DiscsThe spine contains 23 intervertebral discs that absorb load, distribute forces, maintain spacing, and allow flexibility. Each disc consists of a nucleus pulposus, a gel-like core...
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Herniated Intervertebral Disc l: Introduction01:29

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Intervertebral disc herniation refers to the displacement of the nucleus pulposus (the gel-like inner core of the disc) through a tear or weakened area in the annulus fibrosus (the outer fibrous ring). The displaced disc material extends beyond the normal boundaries of the disc space and may compress or irritate nearby spinal nerve roots or, less commonly, the spinal cord.Etiology and Risk FactorsHerniation commonly results from degeneration, in which aging reduces disc hydration and...
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Related Experiment Video

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A Proinflammatory, Degenerative Organ Culture Model to Simulate Early-Stage Intervertebral Disc Disease.
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Fibrin in intervertebral disc tissue engineering.

Alessandra Colombini1, Cristina Ceriani, Giuseppe Banfi

  • 11 Laboratory of Experimental Biochemistry and Molecular Biology, IRCCS Galeazzi Orthopaedic Institute , Milan, Italy .

Tissue Engineering. Part B, Reviews
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Summary
This summary is machine-generated.

Fibrin sealant supports intervertebral disc (IVD) cell survival and matrix production for tissue engineering. Further research is needed on fibrin

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Orthopedic Research

Background:

  • Fibrin sealant is a clinically approved biomaterial used for tissue repair.
  • It supports cell viability and extracellular matrix production, making it promising for intervertebral disc (IVD) tissue engineering.
  • Its application in IVD tissue engineering requires further investigation across different study types.

Purpose of the Study:

  • To review the use of fibrin in vitro, in vivo, and in clinical trials for IVD tissue engineering.
  • To evaluate fibrin's efficacy in supporting disc cell functions and matrix formation.
  • To identify knowledge gaps and future research directions for fibrin-based IVD therapies.

Main Methods:

  • Systematic review of in vitro, in vivo, and clinical studies on fibrin for IVD tissue engineering.
  • Analysis of studies involving disc cell culture within fibrin scaffolds.
  • Examination of studies using animal models of disc degeneration and clinical applications.

Main Results:

  • In vitro studies showed fibrin supports disc cell survival and fibrocartilaginous matrix formation, with some differences noted between nucleus pulposus (NP) and annulus fibrosus (AF) cells.
  • Fibrin demonstrated long-term stability and anti-inflammatory properties.
  • In vivo studies using NP injury models indicated that adding differentiated cells to fibrin enhanced matrix production compared to fibrin alone; however, human cells were not used in vivo or clinically.

Conclusions:

  • Fibrin shows potential for IVD tissue engineering by supporting cell functions and matrix production.
  • Future research should explore fibrin for AF lesions, assess mechanical properties of fibrin biomaterials and neo-formed tissues, and conduct in vivo and clinical studies using human disc cells.
  • Further investigation is required to fully elucidate fibrin's role in treating disc degeneration.