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Updated: Apr 27, 2026
Untargeted Metabolomics from Biological Sources Using Ultraperformance Liquid Chromatography-High Resolution Mass Spectrometry UPLC-HRMS
Published on: May 20, 2013
Small molecule specific run acceptance, specific assay operation, and chromatographic run quality assessment:
Eric J Woolf1, Stuart McDougall, Douglas M Fast
1Merck Research Laboratories, WP 75B-300, West Point, Pennsylvania, 19486, USA, woolf@merck.com.
Abstract:
Consensus practices and regulatory guidance for liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) assays of small molecules are more aligned globally than for any of the other bioanalytical techniques addressed by the Global Bioanalysis Consortium. The three Global Bioanalysis Consortium Harmonization Teams provide recommendations and best practices for areas not yet addressed fully by guidances and consensus for small molecule bioanalysis. Recommendations from all three teams are combined in this report for chromatographic run quality, validation, and sample analysis run acceptance.
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