Related Experiment Video For Adolescent
Updated: Apr 27, 2026

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
Published on: August 18, 2020
Neurofunctional changes in adolescent cannabis users with and without bipolar disorder
Samantha M Bitter1, Caleb M Adler, James C Eliassen
1Department of Psychiatry and Behavioral Neuroscience, Division of Bipolar Disorder Research, University of Cincinnati College of Medicine, Cincinnati, OH, USA; University Research Council's (URC) Undergraduate Student Research Fellowship, University of Cincinnati, Cincinnati, OH, USA; School of Energy, Environmental, Biological and Medical Engineering, College of Engineering and Applied Science, University of Cincinnati, Cincinnati, OH, USA.
Aims:
To compare regional brain activation among adolescents with bipolar disorder and co-occurring cannabis use disorder.
Design:
Cross-sectional study.
Setting:
Cincinnati, OH, USA.
Participants:
Adolescents with bipolar disorder (BP, n = 14), adolescents with cannabis use disorder (MJ, n = 13), adolescents with co-occurring cannabis use and bipolar disorders (BPMJ, n = 25) and healthy adolescents (HC, n = 15).
Measurements:
Cannabis craving, substance use, Blood Oxygenation Level Dependent (BOLD) signal assessed by the Marijuana Craving Questionnaire (MCQ), Teen-Addiction Severity Index (T-ASI) and a cannabis cue-reactivity task during a functional magnetic resonance imaging (fMRI) session, respectively.
Findings:
The BP group exhibited significantly greater brain activation than the BPMJ group in the right amygdala (F = 4.14, P = 0.046), left nucleus accumbens (F = 3.8, P = 0.02), left thalamus (F = 3.8, P < 0.05) and the right thalamus (F = 6.2, P = 0.02). The BP group exhibited significantly greater activation than the HC group in the left nucleus accumbens (F = 11.5, P = 0.0001), right thalamus (F = 4.9, P = 0.03) and the left striatum (F = 3.6, P = 0.04). Left amygdala activation of the BPMJ group trended towards being significantly negatively correlated with the number of joints smoked (R = -0.4, P = 0.06).
Conclusions:
Bipolar adolescents with comorbid cannabis use do not exhibit the same over-activation of the regions involved in emotional processing as seen in adolescents with bipolar disorder alone. The absence of these findings in patients with comorbid bipolar and cannabis use disorders suggests that these individuals may have a unique endophenotype of bipolar disorder or that cannabis use may alter brain activation uniquely in bipolar disorder patients who use cannabis.
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