Related Experiment Video
Updated: Apr 27, 2026

Antibiotic Dereplication Using the Antibiotic Resistance Platform
Published on: October 17, 2019
Applications of structure-based design to antibacterial drug discovery
Ricky Cain1, Sarah Narramore1, Martin McPhillie1
1School of Chemistry, University of Leeds, Leeds LS2 9JT, UK.
Abstract:
In recent years bacterial resistance has been observed against many of our current antibiotics, for instance most worryingly against the cephalosporins which are typically the last line of defence against many bacterial infections. Additionally the failure of high throughput screening in the discovery of new antibacterial drug leads has led to a decline in the number of antibacterial agents reaching the market. Alternative methods of drug discovery including structure based drug design are needed to meet the threats caused by the emergence of resistance. In this review we explore the latest advancements in the identification of new antibacterial agents through the use of a number of structure based drug design programs.
Related Concept Videos
Structure-Activity Relationships and Drug Design
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
Drug Discovery: Overview
Antibiotic Selection
Combined Effects of Drugs: Synergism
Such synergistic combinations...
Production of Antibiotics
Inhibitors of Bacterial Protein Synthesis

