Related Experiment Video
Updated: Apr 27, 2026

Use of an Influenza Antigen Microarray to Measure the Breadth of Serum Antibodies Across Virus Subtypes
Published on: July 26, 2019
Prevalence and determinants of influenza vaccine coverage at tertiary pediatric hospitals
James Newcombe1, Rajneesh Kaur1, Nicholas Wood1
1Sydney Children's Hospitals Network, Department of Immunology and Infectious Diseases, High St. Randwick, NSW 2031, Australia.
Insights
Influenza vaccination uptake is low in Australian children with high-risk conditions, despite missed opportunities during clinic visits. Parental beliefs and healthcare provider recommendations significantly influence vaccine acceptance.
Area of Science:
- Pediatrics
- Public Health
- Immunization
Background:
- Influenza vaccination is recommended for children with high-risk medical conditions.
- Low vaccination rates persist in this vulnerable pediatric population.
- Understanding factors influencing vaccine acceptance is crucial for improving public health outcomes.
Purpose of the Study:
- To examine influenza vaccination uptake in a cohort of Australian children.
- To identify factors associated with influenza vaccine acceptance among children with high-risk conditions.
- To inform strategies for increasing pediatric influenza immunization rates.
Main Methods:
- A cohort of 316 parents of children attending pediatric outpatient clinics in Sydney were recruited.
- Vaccination coverage rates were assessed for children with high-risk versus standard-risk conditions.
- Factors influencing vaccine uptake, including healthcare provider recommendations and parental beliefs, were analyzed.
Main Results:
- Influenza vaccination coverage was 41% in high-risk children and 14% in standard-risk children.
- High-risk children experienced a median of three missed vaccination opportunities during clinic visits.
- Healthcare worker recommendation, high-risk status, and parental beliefs were key determinants of vaccine uptake.
Conclusions:
- Significant gaps exist in influenza vaccination coverage for high-risk children in Australia.
- Missed clinical opportunities highlight a need for improved vaccination strategies.
- Further research into healthcare provider practices and parental beliefs is essential to enhance pediatric influenza immunization.
Abstract:
Despite long-standing recommendations, the uptake of influenza vaccination in children with high risk medical conditions is low. This study aimed to examine the uptake of influenza vaccination amongst a cohort of Australian children and factors associated with vaccine acceptance. Three hundred and sixteen parents of children attending outpatient clinics at the two pediatric hospitals in Sydney were recruited. The reported vaccination coverage rate was 41% among children with high risk conditions and 14% among standard risk children. There was a median of three clinic visits per high risk child at which an opportunity to vaccinate was apparently missed. Healthcare worker recommendation, having a high risk condition and parental beliefs about influenza and influenza vaccination were the most important determinants of vaccine uptake. Further studies on the beliefs and practices of doctors in this area will help guide interventions to improve vaccination rates in high risk children.
Related Concept Videos
Vaccinations
Influenza
Pharmacokinetics in Pediatric Patients: Drug Distribution
Pharmacokinetics in Pediatric Patients: Drug Excretion
Infectious Diseases and Their Occurrence
Drug Dosing: Infants and Children

