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Clotting and fibrinolytic activities of Bacteroides melaninogenicus

G Pulverer, H L Ko, Z Wegrzynowicz

    Zentralblatt Fur Bakteriologie, Parasitenkunde, Infektionskrankheiten Und Hygiene. Erste Abteilung Originale. Reihe A: Medizinische Mikrobiologie Und Parasitologie
    |December 1, 1977
    PubMed

    Insights

    Bacteroides melaninogenicus strains produce extracellular factors that can clot blood and activate fibrinolysis. Many strains exhibited these activities, with some producing only one factor.

    Area of Science:

    • Microbiology
    • Hematology
    • Bacteriology

    Background:

    • Bacteroides melaninogenicus is a species of bacteria.
    • Extracellular factors produced by bacteria can influence host physiology.
    • Blood clotting and fibrinolysis are critical hemostatic processes.

    Purpose of the Study:

    • To investigate the production of extracellular blood clotting and fibrinolytic factors by Bacteroides melaninogenicus.
    • To determine the prevalence of these activities among different subspecies.

    Main Methods:

    • Testing 106 strains of Bacteroides melaninogenicus (ss. asaccharolyticus, intermedius, and melaninogenicus).
    • Assessing the production of extracellular blood clotting factors using rabbit plasma.
    • Evaluating the activation of human plasminogen for fibrinolytic activity.

    Main Results:

    • 78.3% of tested strains demonstrated blood clotting activity.
    • 79.2% of tested strains activated human plasminogen.
    • Strains producing either clotting or fibrinolytic factors exclusively were identified.

    Conclusions:

    • Bacteroides melaninogenicus commonly produces extracellular factors affecting hemostasis.
    • These factors possess significant clotting and fibrinolytic potential.
    • The identified factors are rapidly active under experimental conditions.

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