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A positive feedback loop between RIP3 and JNK controls non-alcoholic steatohepatitis

Jérémie Gautheron1, Mihael Vucur2, Florian Reisinger3

  • 1Department of Gastroenterology, Digestive Diseases and Intensive Care Medicine (Department of Medicine III), University Hospital RWTH Aachen, Aachen, Germany Interdisciplinary Centre for Clinical Research Aachen, University Hospital RWTH Aachen, Aachen, Germany.

EMBO Molecular Medicine
|June 26, 2014
PubMed
Summary

RIP3-dependent necroptosis drives liver fibrosis in non-alcoholic steatohepatitis (NASH). This pathway, involving JNK activation and inflammation, presents a potential therapeutic target for NASH patients.

Keywords:
Caspase‐8MCP‐1biliary ductular reactionliver fibrosisnecroptosis

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