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Determinants of uncontrolled hypertension in an Iranian population
Somayeh Arabzadeh1, Masoumeh Sadeghi2, Katayoun Rabiei3
1Resident, Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
Insights
Obesity significantly increases the risk of uncontrolled hypertension, especially in males. Maintaining a healthy weight is crucial for managing blood pressure effectively in hypertensive patients.
Area of Science:
- Cardiology
- Public Health
- Epidemiology
Background:
- Uncontrolled hypertension is a significant health concern.
- Factors contributing to uncontrolled hypertension include lifestyle, knowledge, attitude, and treatment effectiveness.
Purpose of the Study:
- To investigate the factors contributing to uncontrolled hypertension.
Main Methods:
- Cross-sectional study of hypertensive participants in the Isfahan Healthy Heart Program.
- Data collected via questionnaire and anthropometric/blood pressure measurements.
- Statistical analysis included Chi-square, t-tests, and stepwise logistic regression.
Main Results:
- Over 60% of participants had uncontrolled blood pressure.
- Obesity (BMI > 25 kg/m2) was the strongest predictor of uncontrolled blood pressure (OR=13.09).
- Male gender increased risk (OR=8.47), while inappropriate attitude decreased risk (OR=0.047).
Conclusions:
- Obesity is a primary driver of uncontrolled blood pressure.
- Weight management is essential for hypertensive patients.
- Monitoring and controlling weight are critical for effective hypertension management.
Background:
Uncontrolled hypertension, a major concern among hypertensive patients, may be caused by various factors such as inadequate knowledge and inappropriate attitude, unhealthy lifestyle, and ineffective treatment. The present study tried to cast light on factors leading to uncontrolled hypertension.
Methods:
In this cross-sectional study, all hypertensive participants of the third phase of the Isfahan Healthy Heart Program were contacted and invited to take part in the study. A questionnaire including knowledge of and attitude toward hypertension and its control and treatment methods, and practice about lifestyle and pharmacological treatment was completed for all patients who consented to participate. The participants' anthropometric indices and blood pressure were then measured. Chi-square and Student's t-tests were used to compare the groups with controlled and uncontrolled blood pressure. The effect of each factor on uncontrolled blood pressure was assessed by employing stepwise logistic regression.
Results:
Of 114 participants, 43 (37.12%) and 71 (62.28%) individuals had controlled and uncontrolled blood pressure, respectively. Stepwise logistic regression revealed body mass index > 25 kg/m2 to have the greatest effects on uncontrolled blood pressure [Odds ratio (OR) = 13.091, Confidence interval of 95% (95% CI): 1.437-116.352, P = 0.021). In addition, male gender increased the risk for uncontrolled blood pressure (OR = 8.475, CI95%: 1.276-56.313, P = 0.027), while inappropriate attitude decreased the mentioned risk (OR = 0.047, CI95%: 0.007-0.318, P = 0.002).
Conclusion:
According to our findings, obesity is the most important cause of uncontrolled blood pressure. Therefore, weight has to be closely monitored and controlled in hypertensive patients.
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Factors affecting Blood pressure
Physiological Factors:
Hypertension IV: Drug Therapy and Lifestyle Modifications
Hypertension III: Clinical Manifestations and Diagnostic Studies
Hypertension II: Pathophysiology

