Related Experiment Video
Updated: Apr 27, 2026

Isolation of Human Primary Valve Cells for In vitro Disease Modeling
Published on: April 16, 2021
Atrioventricular block as the initial presentation of calcified bicuspid aortic valve
Reza Karbasi-Afshar1, Nematollah Jonaidi-Jafari2, Amin Saburi3
1Department of Cardiovascular Diseases, School of Medicine AND Atherosclerosis Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Insights
Bicuspid aortic valve (BAV) can lead to severe heart conditions. Early diagnosis and management are crucial to prevent complications like irreversible atrioventricular block after aortic valve replacement.
Area of Science:
- Cardiology
- Congenital Heart Disease
Background:
- Bicuspid aortic valve (BAV) is a common congenital heart defect in adults.
- Delayed diagnosis of congenital heart disorders can lead to disease progression and complications.
Observation:
- A 34-year-old male with BAV presented with cardiac shock due to complete heart block, requiring pacemaker implantation.
- Echocardiography revealed a thick, calcified bicuspid aortic valve with aortic insufficiency, stenosis, and a dilated ascending aorta.
- The patient underwent aortic valve replacement, ascending aorta aneurysm repair (Bentall procedure), and ICD implantation.
Findings:
- Thick, calcified aortic root is a potential risk factor for atrioventricular (AV) block post-aortic valve replacement (AVR).
- Irreversible AV block necessitating permanent pacemaker (PPM) implantation is a rare complication following AVR.
Implications:
- Preoperative assessment for conductive disorders is essential in AVR candidates, particularly those with calcified valves.
- Understanding risk factors for AV block can improve patient outcomes after AVR.
Background:
Bicuspid aortic valve (BAV) is one of the most common and important congenital heart disorders in adults. If a patient with congenital disorders is not diagnosed early, the patient's disease may progress to a severe condition and thus diagnosis of the main disorder will be rendered difficult.
Case Report:
A 34 year-old male patient referred to a referral medical care unit for cardiac electrophysiological study with cardiac shock due to complete heart block 3 months ago and he underwent Dual-Chamber permanent pacemaker (PPM) implantation. Thick and calcified bicuspid AV with invasion to interventricular septum, moderate to severe valve insufficiency (AI), severe aortic valve stenosis (AS), and dilated ascending aorta were observed at his echocardiography. Aortic valve replacement (AVR), aneurysm of ascending aorta, root replacement with tube graft (Bentall Procedure), and also a 3 chambers intracardiac defibrillator (ICD) were used. After 2 weeks of operation, he was discharged and at the first post-hospitalization visit (1 week later), his cardiovascular condition was acceptable.
Conclusion:
Thick calcified aortic root is a less studied and potential contributing risk factor for AV block after AVR. Therefore, in candidates of aortic valve replacement, considering conductive disorders, especially in patients with calcified valve, is mandatory. Irreversible AV block requiring PPM implantation is a rare condition following AVR.
More Related Videos
04:30Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat
Published on: February 4, 2021
05:47Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro
Published on: May 10, 2021
Related Concept Videos
Aortic Regurgitation II: Clinical Features and Diagnostic Tests
Mitral Stenosis II: Clinical features and Diagnostic Tests
Aortic Regurgitation I: Introduction
Mitral Stenosis I: Introduction
Mitral Valve Prolapse I: Introduction
Mitral Regurgitation I: Introduction