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Triamterene nephrolithiasis.

D P Dooley, M E Callsen, J A Geiling

    Military Medicine
    |March 1, 1989
    PubMed
    Summary
    This summary is machine-generated.

    Triamterene, a diuretic, can cause kidney stones and infection, necessitating surgical removal. This case highlights the risks of prescribing it without monitoring potassium levels, especially when combined with other diuretics.

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    Area of Science:

    • Nephrology
    • Pharmacology

    Background:

    • Triamterene is a potassium-sparing diuretic often prescribed for hypertension.
    • Concurrent use with thiazide diuretics like hydrochlorothiazide is common.
    • Nephrolithiasis is a known but infrequent adverse effect of triamterene.

    Observation:

    • A 59-year-old male developed a triamterene-induced renal stone and pyelonephritis.
    • The patient was on a combination of hydrochlorothiazide and triamterene.
    • No prior history of hypokalemia was noted in the patient.

    Findings:

    • The case required percutaneous lithotomy for stone removal.
    • The review covers indications for potassium replacement therapy.
    • Risks associated with triamterene nephrolithiasis are discussed.

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    Implications:

    • Highlights the importance of careful patient selection and monitoring when prescribing triamterene.
    • Underscores the potential for drug-induced kidney stones even without predisposing factors.
    • Emphasizes the need to review medication regimens for potential adverse effects.