Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Renal involvement in leprosy.

P Ponce1, A Ramos, M L Ferreira

  • 1Renal Department, Curry Cabral Hospital, Lisbon, Portugal.

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
|January 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Strain induced in the condyle by self-tapping screws in the Biomet alloplastic temporomandibular joint: a preliminary experimental study.

International journal of oral and maxillofacial surgery·2015
Same author

Comparative assessment of different reconstructive techniques of distal femur in revision total knee arthroplasty.

Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA·2015
Same author

Mucosal leishmaniasis mimicking squamous cell carcinoma in a liver transplant recipient.

Transplant infectious disease : an official journal of the Transplantation Society·2015
Same author

Prediction at long-term condyle screw fixation of temporomandibular joint implant: A numerical study.

Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery·2015
Same author

Kidney transplantation with organs from donors after circulatory death type 3: a prospective multicentric Spanish study (GEODAS 3).

Transplantation proceedings·2015
Same author

Pseudo-dynamic analysis of a cemented hip arthroplasty using a force method based on the Newmark algorithm.

Computer methods in biomechanics and biomedical engineering·2014
Same journal

Evidence-Based Medicine versus Personalized Medicine when attempting to block complement in IgA nephropathy.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2026
Same journal

Impact of immunosuppressive therapy on renal and patient survival in rapidly progressive secondary IgA nephropathy.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2026
Same journal

Severe Pregnancy-Associated Acute Kidney Injury and Maternal Vulnerability.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2026
Same journal

Correction to: Hyponatraemia-treatment standard 2024.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2026
Same journal

Effect of Semaglutide on Measured vs Estimated Glomerular Filtration Rate.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2026
Same journal

Beyond Diffusion and Convection: Is Adsorption the Third Dimension of Dialysis?

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2026
See all related articles

Hansen's disease (leprosy) frequently causes kidney issues like proteinuria and impaired concentration, primarily due to amyloidosis in lepromatous leprosy patients. These renal changes often lack clear clinical symptoms.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Pathology

Background:

  • Renal complications are recognized in Hansen's disease (leprosy).
  • The spectrum and incidence of kidney involvement require further elucidation, particularly in relation to disease type and reactions.

Purpose of the Study:

  • To evaluate the prevalence and nature of renal involvement in Portuguese patients with Hansen's disease.
  • To investigate the association between renal pathology, disease type, and erythema nodosum leprosum (ENL) reactions.

Main Methods:

  • Retrospective and prospective study of 94 Hansen's disease patients.
  • Renal biopsy, fat-tissue aspiration for amyloidosis, and renal tubular function tests were performed.
  • Urinary sediment analysis and assessment of proteinuria/hematuria were conducted.

Related Experiment Videos

Main Results:

  • Mild proteinuria and/or hematuria occurred in 33% of patients, worsening during ENL reactions.
  • Renal amyloidosis was diagnosed in 10.5% of prospectively studied patients, predominantly in lepromatous leprosy with ENL.
  • Renal biopsies revealed mesangial glomerulonephritis and acute tubular necrosis in two cases, without immune deposits.
  • Tubular dysfunction included impaired urine concentration in 6/9 patients and distal acidification defects in 1/9.

Conclusions:

  • Hansen's disease commonly leads to urinary sediment abnormalities and concentration defects, often subclinical.
  • Proteinuria and glomerular damage in leprosy are primarily attributed to amyloidosis, especially in lepromatous forms with ENL.
  • Kidney involvement in leprosy is frequent but typically mild, with amyloidosis being the main pathological finding.