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Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

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Published on: June 21, 2018

Association between RANTES gene polymorphisms and asthma: a meta-analysis.

Dan Wen¹, Xin Du¹, Shao-Ping Nie¹

¹Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

|June 26, 2014

Summary

This summary is machine-generated.

This meta-analysis indicates that the regulated on activation, normal T cell expressed and secreted (RANTES) -403 G/A gene variant is a risk factor for asthma. However, the RANTES -28C/G polymorphism shows no significant association with asthma development.

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Area of Science:

Immunogenetics
Respiratory Medicine
Genetic Epidemiology

Background:

Recent studies suggest a link between RANTES gene polymorphisms (-403 G/A, -28C/G) and asthma.
Conflicting results exist, necessitating further investigation into these associations.

Purpose of the Study:

To conduct a meta-analysis evaluating the relationship between RANTES polymorphisms and asthma.
To synthesize evidence from multiple studies to determine the genetic risk associated with RANTES variants in asthma.

Main Methods:

Systematic literature search of PubMed, Embase, and Cochrane Library databases.
Data extraction by two independent reviewers.
Pooled odds ratios (OR) with 95% confidence intervals (CI) calculated for meta-analysis.

Main Results:

Eighteen studies included 2558 cases/-403 G/A and 3311 cases/-28C/G.
RANTES -403 G/A polymorphism showed a significant association with asthma (OR 1.19, 1.06-1.33).
RANTES -28C/G polymorphism did not demonstrate a significant association with asthma (OR 1.23, 1.09-1.39).

Conclusions:

The RANTES -403 G/A polymorphism is identified as a risk factor for asthma.
The RANTES -28C/G polymorphism is not associated with asthma.
This meta-analysis provides robust evidence on the role of specific RANTES polymorphisms in asthma pathogenesis.