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Echocardiographic evidence of innate aortopathy in the human intracranial aneurysm

Yong-Won Shin1, Keun-Hwa Jung2, Jeong-Min Kim3

  • 1Department of Neurology, Laboratory for Neurotherapeutics, Biomedical Research Institute, Seoul National University Hospital, Seoul, South Korea.

Plos One
|June 26, 2014
PubMed

Insights

Patients with intracranial aneurysms (IA) and aortopathy, like aortic root dilation, may share a common underlying wall defect. This suggests a link between IA and aortic diseases, potentially stemming from neural crest cell development.

Area of Science:

  • Cardiovascular Medicine
  • Neurology
  • Genetics

Background:

  • Intracranial aneurysms (IA) are more common in patients with coarctation of the aorta or bicuspid aortic valve.
  • This suggests a shared pathophysiology between IA and aortopathy.
  • Aortic root dimension (ARD) in IA patients was analyzed to investigate this connection.

Purpose of the Study:

  • To analyze echocardiographic aortic root dimension (ARD) in patients with intracranial aneurysms (IA).
  • To confirm the possibility of a common pathophysiology linking IA and aortopathy.
  • To compare clinical, angiographic, and echocardiographic findings between eccentric and non-eccentric IA groups.

Main Methods:

  • 260 IA patients undergoing echocardiography from 2008-2010 were enrolled.
  • Patients were classified into eccentric (younger, ruptured, large, or multiple IAs) and non-eccentric groups.
  • ARD and clinical factors were compared between groups.

Main Results:

  • Significantly larger ARD was observed in the eccentric IA group compared to the non-eccentric group (P=0.049).
  • Multivariable analysis confirmed this difference (P=0.02).
  • Hypertension was more prevalent in the non-eccentric group (P=0.01), and height was inversely related to aneurysm size (P=0.004).

Conclusions:

  • A subset of IA patients exhibits a shared intrinsic wall defect with aortopathy.
  • This phenomenon may be linked to a common neural crest cell origin.
  • Findings support a common underlying cause for IA and certain aortic conditions.
Abstract

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