Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

156
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
156
Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

172
Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
172

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Covalently Engineered Metal-Organic Framework Nanosystem for Imaging-Guided Photoimmunotherapy of Metastatic Tumors.

ACS applied materials & interfaces·2026
Same author

The mechanistic of DCBLD2 in inhibiting TGF-β induced endothelial-mesenchymal transition in calcific aortic valve disease.

Journal of molecular and cellular cardiology·2026
Same author

Circulating CTRP9 and aortic valve calcification jointly predict coronary artery calcification in coronary heart disease patients.

Frontiers in nutrition·2026
Same author

Re-Energization Shale Oil Reservoirs with Nanofluid Prefracturing: Mechanism Simulation and Case Study.

ACS omega·2026
Same author

Small Extracellular Vesicle External Surface Adiponectin-Mediated Adipocytes/Cardiomyocytes Communication in Diabetic Ischemic Heart Failure.

Circulation·2026
Same author

Application of ultrasound in combination with other methods in gynecological disease: artificial intelligence, surgery, and drugs.

Frontiers in oncology·2025

Related Experiment Video

Updated: Apr 27, 2026

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

17.8K

Self-assembled nanoscale coordination polymers with trigger release properties for effective anticancer therapy.

Demin Liu1, Christopher Poon1, Kuangda Lu1

  • 1Department of Chemistry, University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA.

Nature Communications
|June 26, 2014
PubMed
Summary

This study introduces zinc bisphosphonate nanoscale coordination polymers (NCPs) for cancer therapy. These NCPs effectively deliver cisplatin and oxaliplatin, showing enhanced anti-tumor activity and improved drug delivery compared to free drugs.

More Related Videos

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization
06:26

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

Published on: January 24, 2025

1.9K
Facile Preparation and Photoactivation of Prodrug-Dye Nanoassemblies
08:54

Facile Preparation and Photoactivation of Prodrug-Dye Nanoassemblies

Published on: February 17, 2023

1.7K

Related Experiment Videos

Last Updated: Apr 27, 2026

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

17.8K
Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization
06:26

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

Published on: January 24, 2025

1.9K
Facile Preparation and Photoactivation of Prodrug-Dye Nanoassemblies
08:54

Facile Preparation and Photoactivation of Prodrug-Dye Nanoassemblies

Published on: February 17, 2023

1.7K

Area of Science:

  • Materials Science
  • Nanotechnology
  • Drug Delivery

Background:

  • Nanoscale coordination polymers (NCPs) offer advantages over traditional drug delivery systems due to their tunable properties.
  • Existing cancer therapies face challenges with drug loading, circulation time, and targeted delivery.

Purpose of the Study:

  • To develop and evaluate zinc bisphosphonate NCPs as a novel nanotherapeutic platform for cancer treatment.
  • To assess the drug loading capacity, pharmacokinetics, and anti-tumor efficacy of NCPs carrying cisplatin and oxaliplatin prodrugs.

Main Methods:

  • Self-assembly of zinc bisphosphonate NCPs.
  • Loading of cisplatin and oxaliplatin prodrugs into NCPs.
  • In vivo pharmacokinetic studies in mice using pegylated NCPs.
  • Evaluation of anti-tumor efficacy in various tumor xenograft models (colon, lung, pancreatic cancer).

Main Results:

  • Zinc bisphosphonate NCPs successfully encapsulated high amounts of cisplatin (48 ± 3 wt%) and oxaliplatin (45 ± 5 wt%).
  • Pegylated NCPs exhibited prolonged blood circulation half-lives (16.4 ± 2.9 h for cisplatin, 12.0 ± 3.9 h for oxaliplatin) and minimal mononuclear phagocyte system uptake.
  • NCPs demonstrated superior anti-tumor potency and efficacy compared to free drugs across multiple cancer models.

Conclusions:

  • This study establishes zinc bisphosphonate NCPs as a viable and promising nanodrug delivery platform for cancer therapy.
  • NCPs offer enhanced anti-tumor activity and improved pharmacokinetic profiles, representing a significant advancement in nanotherapeutics.