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Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage
Published on: August 4, 2021
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Is superfertility associated with recurrent pregnancy loss?
Jennie Orlando1, Carolyn Coulam
1Rosalind Franklin University, North Chicago, IL, USA.
Summary
Superfertility, defined as high monthly fecundity rates, affects 32% of women with recurrent pregnancy loss. This condition, along with immunologic factors and chromosomal abnormalities, contributes to implantation failure.
Area of Science:
- Reproductive Medicine
- Genetics
- Immunology
Background:
- Recurrent pregnancy loss (RPL) is a complex condition with various potential causes.
- A recent hypothesis suggests superfertility may contribute to RPL.
- Superfertility is characterized by high monthly fecundity rates.
Purpose of the Study:
- To investigate the prevalence of superfertility in women with RPL.
- To identify other potential risk factors for RPL, including immunologic factors and chromosomal abnormalities.
- To determine the association between these factors and RPL.
Main Methods:
- A retrospective review of clinical histories for 201 women with RPL.
- Recording of months to desired pregnancy, karyotypes of products of conception, and laboratory test results.
- Laboratory tests included antiphospholipid antibodies (APA), LA, CD56(+) cells, and NK cytotoxicity.
Main Results:
- Superfertility was found in 32% of women with RPL, significantly higher than the general population (3%).
- Immunologic risk factors (APA, LA, increased CD56(+) cells, or NK cytotoxicity) were present in 30% of patients.
- Chromosomal abnormalities occurred in 20% of pregnancy losses, with 80% being normal karyotypes.
Conclusions:
- Recurrent pregnancy loss is associated with superfertility in 32% of cases.
- Immunologic risk factors and chromosomal abnormalities are also significant contributors to RPL.
- Implantation failure in RPL may stem from both excessive (superfertility) and insufficient implantation factors.
Keywords:
immunologic risk factorskaryotype products of conceptionrecurrent pregnancy losssuperfertilityMore Related Videos
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