Colonic perforation associated with neostigmine administration
Related Experiment Video
Updated: Apr 27, 2026

Murine Ileocolic Bowel Resection with Primary Anastomosis
Published on: October 29, 2014
Christopher R McDonald1, Darren Tonkin2, Peter Hewett2
1Department of Colorectal Surgery, The Queen Elizabeth Hospital, Woodville South, SA, Australia attentionchris@gmail.com.
Abstract:
Neostigmine is an acetylcholinesterase inhibitor that is increasingly used as a medical treatment in cases of pseudo-obstruction. It has a well-recognized side-effect profile that includes bradycardia and bronchospasm. We present a case of colonic perforation after administration of neostigmine in the treatment of pseudo-obstruction.
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