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Liver Regeneration

Liver Regeneration

The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...

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Related Experiment Video

Updated: Apr 27, 2026

Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy ALPPS Procedure

Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy ALPPS Procedure

Published on: August 14, 2017

Advances in liver regeneration.

George K Michalopoulos¹

¹Department of Pathology, University of Pittsburgh School of Medicine, Bioscience Tower South, Pittsburgh, PA 15261, USA.

Expert Review of Gastroenterology & Hepatology

|June 27, 2014

Summary

Mammalian liver regeneration restores original organ size through a

Area of Science:

Regenerative medicine
Mammalian organogenesis
Hepatology

Background:

Partial hepatectomy triggers liver regeneration, a unique mammalian process.
Liver weight adjusts to body needs, indicating a 'hepatostat' control system.
Initiation mechanisms are understood, but termination pathways are key to hepatostat control and hepatic neoplasia.

Purpose of the Study:

Investigate liver regeneration termination pathways.
Elucidate the 'hepatostat' control mechanisms.
Explore the role of epithelial cell plasticity in regeneration failure.

Main Methods:

Review of existing literature on liver regeneration.
Analysis of control points in hepatocyte and biliary epithelial cell proliferation.

Keywords:

EGFR HGF extracellular matrix facultative stem cell integrin linked kinase liver regeneration

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Isolation of Regenerating Hepatocytes after Partial Hepatectomy in Mice

Published on: December 2, 2022

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Last Updated: Apr 27, 2026

Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy ALPPS Procedure

Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy ALPPS Procedure

Published on: August 14, 2017

Author Spotlight: Evaluating Therapeutic Strategies to Enhance Liver Regeneration

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Published on: May 24, 2024

Isolation of Regenerating Hepatocytes after Partial Hepatectomy in Mice

Isolation of Regenerating Hepatocytes after Partial Hepatectomy in Mice

Published on: December 2, 2022

Examination of stem cell plasticity between epithelial compartments.

Main Results:

Termination pathways are crucial for regulating the 'hepatostat'.
Elimination of these pathways may link to hepatic neoplasia.
In regeneration failure, hepatocytes and biliary cells exhibit facultative stem cell potential.

Conclusions:

Understanding termination pathways is vital for controlling liver size and preventing neoplasia.
Facultative stem cell capacity in both epithelial compartments offers insights into regenerative failure.
Further research into the hepatostat is warranted.