Related Experiment Videos
Meningioangiomatosis: a case report
S S Liu1, P C Johnson, V K Sonntag
1Division of Neurological Surgery, Barrow Neurological Institute, Phoenix, Arizona.
Abstract:
A case of meningioangiomatosis without neurofibromatosis, a rare disorder, is described. These patients are usually young (mean age, 27 years) and frequently present with seizures that resolve following partial or total resection of the lesion. The lesions are firm and well demarcated grossly with areas of calcification. Only single lesions have been described. Neurofibrillary tangles, noted in the present case, have been reported previously, but their significance remains uncertain. The lesion are benign and surgery is recommended.
Insights
Meningioangiomatosis, a rare disorder, typically affects young adults and causes seizures. Surgical resection of these benign brain lesions often resolves symptoms, even in cases without neurofibromatosis.
Area of Science:
- Neurology
- Neurosurgery
- Pathology
Background:
- Meningioangiomatosis is a rare, benign neoplastic proliferation of meningothelial and vascular elements.
- It typically presents in young adults with neurological symptoms, most commonly seizures.
- While often associated with neurofibromatosis, cases without this comorbidity are documented.
Observation:
- This report details a case of meningioangiomatosis occurring independently of neurofibromatosis.
- The lesion was characterized as firm, well-demarcated, and containing areas of calcification.
- Neurofibrillary tangles were observed within the lesion, a finding noted in prior literature but of uncertain significance.
Findings:
- The patient, a young adult, presented with seizures attributable to the meningioangiomatosis lesion.
- Surgical intervention, involving partial or total resection of the lesion, led to seizure resolution.
- The benign nature of the lesion was confirmed histopathologically.
Implications:
- This case reinforces that meningioangiomatosis can occur without neurofibromatosis.
- Surgical resection is an effective treatment for seizure control in meningioangiomatosis.
- Further research may elucidate the role of neurofibrillary tangles in the pathogenesis of this disorder.