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Updated: Apr 27, 2026

Detection of Neutralization-sensitive Epitopes in Antigens Displayed on Virus-Like Particle VLP-Based Vaccines Using a Capture Assay
Published on: February 10, 2022
The value of HIV protective epitope research for informed vaccine design against diverse viral pathogens
Victor G Kramer1, Siddappa N Byrareddy
1McGill AIDS Centre, Lady Davis Institute, Jewish General Hospital, Montreal, QC, Canada.
Abstract:
The success of vaccine regimens against viral pathogens hinges on the elicitation of protective responses. Hypervariable pathogens such as HIV avoid neutralization by masking protective epitopes with more immunogenic decoys. The identification of protective, conserved epitopes is crucial for future vaccine candidate design. The strategies employed for identification of HIV protective epitopes will also aid towards rational vaccine design for other viral pathogens.
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