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Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
Podoplanin--a novel marker in oral carcinogenesis
Niharika Swain1, Shwetha V Kumar, Samapika Routray
1Department of Oral Pathology, MGM Dental College and Hospital, 304, Siddhi Vinayak Residency Sector 9, Plot no. 40 Kamothe, Navi Mumbai, 410209, Maharashtra, India, niharikadec30@gmail.com.
Abstract:
Podoplanin, a transmembrane sialoglycoprotein, is a specific marker for lymphatic endothelial cells which in recent years has gained prominent notoriety for its role in tumor progression and metastasis. It is an extensively studied biomarker for predictive assessment of malignant transformation as well as biologic behavior in both human precancer and cancer, respectively. This review summarizes the association of podoplanin overexpression in oral potentially malignant disorders and oral cancer with special emphasis on its putative role in carcinogenesis as well as its prospective use in targeted therapy.
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