Postnatal Toxicity in Mice Attributable to Plastic Leachables in Peritoneal Dialysis Solution (PDS)

Peritoneal dialysis solution (PDS), widely used to treat uremia and renal failure, may contain toxicants that have leached from their plastic storage bags. In this study, PDS was administered intraperitoneally (i.p.) into lactating mice to investigate effects in the offspring. Treatment started from the first day of delivery until weaning. Ten lactating dams were given PDS from a bag stored at room temperature (25°C). Another 10 received PDS from a bag preheated (50°C) overnight. A third 10 were given the control PDS. Following weaning, the offspring were subjected to various biochemical and hematological tests. The significant (p≤.05) effects were elevation in alanine aminotransferase (ALT), aspartate aminotransferase (AST), nonprotein nitrogenous compounds (NPN), potassium, and triglycerides; drop in high-density lipoprotein (HDL) cholesterol; rise in monocytes and granulocytes; and drop in lymphocyte. Preheating seems to have no effect on leachability rate, producing similar effects in offspring, compared with the control. These effects could be attributable to leachables from bags of the investigated PDS.