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Aspartame and Risk of Cancer: A Meta-analytic Review

Sreekanth Mallikarjun1, Rebecca McNeill Sieburth

  • 1a Department of Technology and Society, Stony Brook University , Stony Brook , New York , USA.

Archives of Environmental & Occupational Health
|June 27, 2014
PubMed

Insights

Aspartame (APM), a common artificial sweetener, has raised cancer concerns. A meta-analysis of rodent studies indicates no significant carcinogenic effect from APM consumption.

Area of Science:

  • Toxicology
  • Food Science
  • Oncology

Background:

  • Aspartame (APM) is a widely used artificial sweetener and flavor enhancer.
  • Recent concerns regarding APM's potential carcinogenicity have emerged due to conflicting study findings.

Purpose of the Study:

  • To conduct a meta-analytic review of rodent bioassays on APM carcinogenicity.
  • To aggregate findings from studies published before December 31, 2012.

Main Methods:

  • Systematic literature search for APM carcinogenic bioassays on rodents.
  • Meta-analysis of 10 identified original studies.
  • Aggregate effect size calculation to determine overall carcinogenic potential.

Main Results:

  • The meta-analysis included 10 rodent bioassays on aspartame.
  • Aggregate effect sizes showed no statistically significant carcinogenic effect of APM.
  • Findings suggest APM consumption is not linked to cancer in rodents.

Conclusions:

  • Based on available rodent studies, aspartame consumption does not pose a significant carcinogenic risk.
  • The meta-analysis provides a consolidated view of early evidence on APM safety.
  • Further research may be warranted to address ongoing public health concerns.
Keywords:
aspartamecancermeta-analysis

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