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Serum cholesterol and triglycerides in hematological malignancies.

A Marini1, G Carulli, A Azzarà

  • 1Servizio di Ematologia e Clinica Medica I, University of Pisa, Italy.

Acta Haematologica
|January 1, 1989
PubMed
Summary

Hypocholesterolemia, or low total cholesterol, is common in patients with hematological malignancies, particularly advanced stages. This finding suggests cholesterol may be a secondary marker for monitoring these cancers.

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Area of Science:

  • Hematology
  • Oncology
  • Biochemistry

Background:

  • Hematological malignancies encompass a range of blood cancers.
  • Serum lipid profiles, including cholesterol and triglycerides, can be affected by various disease states.

Purpose of the Study:

  • To investigate serum total cholesterol and triglyceride levels at diagnosis in patients with hematological malignancies.
  • To explore correlations between lipid levels and disease characteristics, including clinical stage and hematological parameters.

Main Methods:

  • Serum samples were collected from 202 patients diagnosed with hematological malignancies.
  • Levels of total cholesterol and triglycerides were measured.
  • Data were analyzed for correlations with disease type, clinical stage, and hematological parameters (WBC, blasts, splenomegaly, hemoglobin, hematocrit).

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Main Results:

  • Hypocholesterolemia was observed in 44% of patients with lymphoproliferative diseases and acute lymphoblastic leukemia, strongly correlating with advanced stages (67.8%).
  • In acute and chronic myeloproliferative diseases, 71% of patients exhibited hypocholesterolemia, with higher incidence in chronic myeloid leukemia and idiopathic myelofibrosis compared to polycythemia vera.
  • No significant correlation was found between cholesterol levels and major hematological parameters in myeloproliferative diseases. Triglyceride alterations were negligible.

Conclusions:

  • Hypocholesterolemia is a notable biological aspect of hematological malignancies.
  • Serum total cholesterol may serve as a secondary monitoring parameter in the follow-up of hematological neoplastic diseases.