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Related Experiment Videos

Solid oral forms availability in children: a cost saving investigation.

Audrey Lajoinie1, Emilie Henin, Behrouz Kassai

  • 1EPICIME-CIC 1407 Inserm, Service de Pharmacologie Clinique, Hospices Civils de Lyon Lyon, F-69677, Bron, France; Université Lyon 1, UMR 5558 CNRS, Laboratoire de Biométrie et Biologie Evolutive, F-69622, Villeurbanne, France.

British Journal of Clinical Pharmacology
|June 27, 2014
PubMed
Summary
This summary is machine-generated.

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Substituting liquid medicines with solid forms for children over 2 years could lead to significant cost savings. This approach offers considerable financial benefits for both hospitals and the community, making it a viable consideration.

Area of Science:

  • Pediatric Pharmacy
  • Pharmaceutical Sciences
  • Health Economics

Background:

  • Oral liquid medicines are commonly prescribed for pediatric patients.
  • Challenges exist in administering liquid medications, including accurate dosing and patient adherence.
  • The cost-effectiveness of alternative dosage forms is an important consideration in pediatric pharmacotherapy.

Purpose of the Study:

  • To evaluate the feasibility of substituting oral liquid medications with solid dosage forms for children over 2 years old.
  • To assess potential cost savings associated with this substitution from both hospital and community perspectives.
  • To determine the suitability of available solid alternatives based on dosage and age-appropriateness.

Main Methods:

  • A 1-week sample of dispensed oral liquid medicines from a UK pediatric hospital was analyzed.
Keywords:
drug formulationoral drug deliverypaediatricswallowing

Related Experiment Videos

  • Screening for available solid form alternatives and assessing their acceptability regarding prescribed dose and child's age.
  • Cost calculations were performed for 28-day treatment durations or prescribed short-term durations.

    • Main Results:

    • Over 90% of liquid formulations had a marketed solid form alternative.
    • Approximately 80% of liquid medications were suitable for substitution based on dosage acceptability criteria.
    • An estimated £5K-£8K weekly savings were identified, projecting annual savings of £238K-£410K per institution.

    Conclusions:

    • Substitution of oral liquid formulations with suitable solid dosage forms can yield substantial drug cost savings.
    • While not all children can swallow solid forms, the financial benefits support further investigation into strategies for facilitating tablet/capsule ingestion in pediatric patients.
    • Solid dosage forms offer numerous advantages over liquids, warranting investment in methods to support their use in children.