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Effect of lipid profile upon prognosis in ischemic and haemorrhagic cerebrovascular stroke

Anuradha Bharosay1, Vivek V Bharosay2, Debapriya Bandyopadhyay3

  • 1Department of Biochemistry, Chirayu Medical College, Bhopal, India.

Indian Journal of Clinical Biochemistry : IJCB
|June 27, 2014
PubMed

Insights

Serum lipid profiles accurately predict stroke prognosis. This study found significant associations between lipid levels and stroke outcomes in patients with ischemic and hemorrhagic cerebrovascular events.

Area of Science:

  • Neurology
  • Cardiovascular Medicine
  • Biochemistry

Background:

  • Stroke is a leading global cause of mortality.
  • The link between serum lipids and cerebrovascular disease is not well-established, unlike its known association with atherosclerosis and coronary heart disease.
  • Understanding lipid profiles' role in stroke prognosis is crucial for patient management.

Purpose of the Study:

  • To evaluate the reliability and accuracy of serum lipid profiles in predicting neurological worsening in patients with ischemic and hemorrhagic stroke.
  • To determine the association between lipid profiles and stroke prognosis.

Main Methods:

  • A case-control study involving 150 cerebrovascular stroke patients (90 ischemic, 60 hemorrhagic) and 101 healthy controls.
  • Fasting lipid profiles were measured within 72 hours of stroke onset for all participants.
  • Statistical analysis was performed to assess associations between lipid parameters and stroke prognosis.

Main Results:

  • A statistically significant association (p < 0.001) was found between lipid profile parameters in stroke patients and healthy controls.
  • Significant associations were also observed between lipid profile parameters and stroke prognosis, indicating their predictive value.

Conclusions:

  • Serum lipid profiles are reliable and accurate indicators for assessing the prognosis of cerebrovascular stroke.
  • Lipid profile analysis can aid in predicting neurological worsening in both ischemic and hemorrhagic stroke patients.

Keywords:
High density lipoprotein-cholesterol (HDL-C)Low density lipoprotein-cholesterol (LDL-C)National Institute of Health Stroke Scale (NIHSS)StrokeTotal cholesterol (TC)Triglycerides (TG)

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