Central corneal thickness measurements in premature infants
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Updated: Apr 27, 2026
Transcutaneous Microcirculatory Imaging in Preterm Neonates
Published on: December 31, 2015
Murat Gunay1, Gokhan Celik1, Betul Onal Gunay2
1Department of Ophthalmology, Zeynep Kamil Women and Childrens' Diseases Education and Research Hospital, Istanbul 34668, Turkey.
Insights
Central corneal thickness (CCT) in premature infants was measured. Thinner corneas were observed in infants with higher gestational age and birth weight.
Area of Science:
- Ophthalmology
- Neonatology
- Pediatric Medicine
Background:
- Premature infants require specialized ophthalmic assessments.
- Understanding central corneal thickness (CCT) is crucial for neonatal eye care.
Purpose of the Study:
- To evaluate central corneal thickness (CCT) measurements in premature infants.
- To investigate the correlation of CCT with gestational age (GA) and birth weight (BW).
Main Methods:
- Retrospective study of premature infants (25-34 weeks GA).
- CCT measurements performed within 48 hours of birth using ultrasonic pachymetry.
- Topical anesthesia applied during measurements.
Main Results:
- Mean CCT was 647.79±63.94 µm across 200 eyes.
- No significant difference in CCT between right and left eyes.
- No significant difference in CCT between genders, but a negative correlation with GA and BW (P<0.01).
Conclusions:
- Premature infant CCT is negatively correlated with gestational age and birth weight.
- These findings aid in understanding corneal development in neonates.
Aim:
To evaluate the central corneal thickness (CCT) measurements of premature infants.
Methods:
The premature infants who were born between 25-34wk of gestational age (GA) were retrieved for the study. All CCT measurements were performed within the first 2d of their life under topical anesthesia by using an ultrasonic pachymeter.
Results:
The mean CCT of 200 eyes was 647.79±63.94 µm. The mean CCT of the right and left eyes were similar (647.30±64.72 µm and 648.29±63.47 µm consecutively). The mean CCT of the girls was 642.08±54.89 µm and the boys was 653.07±71.14 µm, with no statistically significant difference (P>0.05). But there was a negative correlation of the CCT with GA and birth weight (BW) (P<0.01).
Conclusion:
The CCT values of premature babies were negatively correlated with GA and BW.
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