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Obesity01:24

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The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
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Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance, in which target tissues such as the liver, muscle, and adipose tissue respond poorly to insulin. It is also associated with inadequate compensatory insulin secretion, where pancreatic β-cells fail to produce sufficient insulin. Together, these abnormalities lead to persistent hyperglycemia.EtiologyT2DM develops through a complex interaction of genetic predisposition and environmental or...
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Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
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Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
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Related Experiment Video

Updated: Apr 27, 2026

A Primary Human Trophoblast Model to Study the Effect of Inflammation Associated with Maternal Obesity on Regulation of Autophagy in the Placenta
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Maternal obesity, inflammation, and developmental programming.

Stephanie A Segovia1, Mark H Vickers1, Clint Gray1

  • 1Liggins Institute and Gravida, National Centre for Growth and Development, University of Auckland, Auckland 1142, New Zealand.

Biomed Research International
|June 27, 2014
PubMed
Summary
This summary is machine-generated.

Maternal obesity during pregnancy can negatively program offspring, increasing risks for obesity and metabolic disorders. Nutritional anti-inflammatories may offer protective strategies against these long-term health consequences.

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Area of Science:

  • Reproductive Health
  • Developmental Biology
  • Metabolic Disorders

Background:

  • Obesity in women of child-bearing age is a global health concern.
  • Maternal obesity poses risks for gestational complications and long-term offspring health.
  • Developmental programming links early-life environmental factors to later-life disease susceptibility.

Purpose of the Study:

  • To review maternal metainflammation as a mediator of developmental programming in offspring.
  • To explore the role of inflammation in metabolic disorders linked to maternal obesity.
  • To identify potential nutritional interventions for mitigating obesity-induced programming.

Main Methods:

  • Literature review focusing on maternal obesity, inflammation, and offspring metabolic health.
  • Analysis of mechanisms linking maternal environment to offspring development.
  • Evaluation of nutritional anti-inflammatories as intervention strategies.

Main Results:

  • Maternal obesity is associated with low-grade inflammation (metainflammation).
  • Metainflammation may program insulin-sensitive tissues in offspring, predisposing them to metabolic disorders.
  • Nutritional compounds like omega-3 fatty acids, resveratrol, curcumin, and taurine show potential benefits.

Conclusions:

  • Maternal metainflammation is a key mediator in programming offspring metabolic health.
  • Nutritional anti-inflammatories during pregnancy may ameliorate adverse effects of maternal obesity.
  • Targeting inflammation offers a promising strategy to improve long-term offspring health outcomes.