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Skin lesions associated with circulating lupus anticoagulant
V A Alegre1, D A Gastineau, R K Winkelmann
1Department of Dermatology, Mayo Clinic, Rochester, Minnesota.
The British Journal of Dermatology
|March 1, 1989
Summary
Lupus anticoagulation is linked to skin issues like ulcers and necrosis. Recognizing these cutaneous lesions is vital, as they can be an early indicator of systemic thrombotic events in patients.
Area of Science:
- Dermatology
- Hematology
- Rheumatology
Background:
- Lupus anticoagulation is a known risk factor for thrombosis.
- Previous studies suggest an association between lupus anticoagulation and thrombotic events.
Purpose of the Study:
- To investigate the occurrence and types of cutaneous lesions associated with lupus anticoagulation.
- To determine the clinical significance of these skin manifestations in relation to systemic thrombosis.
Main Methods:
- Retrospective study of 295 patients.
- Analysis of patient data to identify cutaneous lesions in those with lupus anticoagulation.
- Categorization of frequent skin lesion types.
Main Results:
- 70 out of 295 patients (23.7%) exhibited cutaneous lesions linked to coagulation defects.
- Most common lesions included thrombophlebitis, skin ulcers, gangrene, hemorrhage, and cutaneous necrosis.
- In 41% of patients with skin lesions, these were the initial sign of the disease.
- Nearly 40% of patients with skin lesions experienced multisystem thrombotic phenomena.
Conclusions:
- Cutaneous lesions are a significant clinical manifestation associated with lupus anticoagulation.
- The presence of skin lesions can indicate an increased risk of systemic thrombotic events.
- Early recognition of these dermatological signs is crucial for managing patients with lupus anticoagulation.