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Inherent anchorages in UiO-66 nanoparticles for efficient capture of alendronate and its mediated release
Xiangyang Zhu1, Jinlou Gu, Yao Wang
1Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China. jinlougu@ecust.edu.cn.
Abstract:
Zr-based MOF nanoparticles were applied as efficient carriers for alendronate delivery, and an unprecedented drug loading capacity was achieved thanks to the inherent drug anchorages of Zr-O clusters therein. The encapsulated drug featured with a pH-dependent release profile, and inhibited the growth of cancer cells more efficiently than the free drug.
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