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Epilepsy and Seizures: Overview01:24

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Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
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Developing the Pediatric Refractory Epilepsy Questionnaire: a pilot study.

Vaishnavi Purusothaman1, Robin C C Ryther2, Mary Bertrand2

  • 1Division of Biology and Biomedical Sciences, Washington University in St. Louis Graduate School of Arts and Sciences, St. Louis, MO, USA.

Epilepsy & Behavior : E&B
|June 27, 2014
PubMed
Summary
This summary is machine-generated.

A new Pediatric Refractory Epilepsy Questionnaire (PREQ) shows promise in assessing medically refractory epilepsy (MRE) in children. This tool helps evaluate seizure control, neurodevelopment, and quality of life for better treatment strategies.

Keywords:
EpilepsyEpilepsy surgeryIntractableMedically refractoryPalliative epilepsy surgeryQuestionnaireSeizure

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Area of Science:

  • Pediatric Neurology
  • Clinical Psychology

Background:

  • Medically refractory epilepsy (MRE) affects up to 14% of children with epilepsy, persisting despite appropriate medical therapy.
  • Assessing outcomes and treatment efficacy in pediatric MRE is challenging due to the lack of a comprehensive quantitative instrument.
  • An ideal instrument should integrate seizure control, neurodevelopment, caregiver burden, and quality of life.

Purpose of the Study:

  • To develop and pilot the Pediatric Refractory Epilepsy Questionnaire (PREQ).
  • The PREQ aims to be a quantitative instrument for assessing the severity and individual burden of epilepsy in children with MRE undergoing palliative treatments.

Main Methods:

  • Caregivers of 25 pediatric MRE patients completed the PREQ and the Quality of Life in Childhood Epilepsy (QOLCE) measure.
  • Patient medical records were reviewed, and scores from the Early Childhood Epilepsy Severity Scale (E-CHESS) and Global Assessment of Severity of Epilepsy (GASE) were obtained.

Main Results:

  • The PREQ underwent modifications based on caregiver feedback, expert review, and analysis of responses.
  • Significant correlations were found between PREQ subscales and validated measures of seizure severity (GASE score) and quality of life (QOLCE).
  • Specific correlations included seizure severity subscale with GASE (r=0.55) and mood subscale with QOLCE well-being score (r=0.61).

Conclusions:

  • This pilot study represents a crucial initial step in developing the PREQ.
  • Preliminary findings support the PREQ's ability to assess epilepsy severity, mood, neurodevelopment, and quality of life.
  • A larger prospective study is ongoing to further refine and validate the PREQ.