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Updated: Apr 27, 2026

Rapid One-step Enzymatic Synthesis and All-aqueous Purification of Trehalose Analogues
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A trehalose ester from Lancea tibetica.

Shi-Jun Liu1, Zhi-Xin Liao, Chao Liu

  • 1a Department of Pharmaceutical Engineering , School of Chemistry and Chemical Engineering, Southeast University , Nanjing 211189 , P.R. China.

Natural Product Research
|June 27, 2014
PubMed
Summary
This summary is machine-generated.

A new trehalose ester from Lancea tibetica demonstrated potent anti-cancer activity, particularly against NCI-H460 lung cancer cells, offering potential for new therapeutic development.

Keywords:
Lancea tibeticaanti-tumour activityflavonetrehalose estertriterpenoid

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Area of Science:

  • Phytochemistry
  • Natural Products Chemistry
  • Pharmacology

Background:

  • Lancea tibetica is a plant with a history of traditional medicinal use.
  • Ethnobotanical knowledge suggests potential therapeutic properties requiring scientific validation.
  • Comprehensive phytochemical analysis is crucial for identifying bioactive constituents.

Purpose of the Study:

  • To conduct a phytochemical investigation of Lancea tibetica.
  • To isolate and characterize novel and known compounds from the plant extract.
  • To evaluate the in vitro anti-proliferative activity of isolated compounds against selected cancer cell lines.

Main Methods:

  • Extraction of the whole plant using 95% ethanol.
  • Isolation of compounds using chromatographic techniques.
  • Structure elucidation of compounds via spectroscopic methods (e.g., NMR, MS).
  • In vitro anti-proliferative assays against MCF-7, NCI-H460, and Hep-G2 cell lines.

Main Results:

  • Isolation of one new trehalose ester, 6-O-undecanoyl-α,β-trehalose (1).
  • Identification of 23 known compounds, with 16 being reported from this plant for the first time.
  • Compound 1 showed potent inhibitory activity against NCI-H460 (lung cancer) cells.
  • Compound 1 exhibited moderate cytotoxic activity against MCF-7 (breast cancer) and Hep-G2 (liver cancer) cells.

Conclusions:

  • The phytochemical study of Lancea tibetica yielded a novel trehalose ester and several known compounds.
  • The new compound, 6-O-undecanoyl-α,β-trehalose, displays significant in vitro anti-proliferative effects, especially against NCI-H460 cells.
  • These findings highlight the potential of Lancea tibetica as a source of anti-cancer agents.