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Double barrier as an effective method for slower delivery rate of ibuprofen
Joanna Kurczewska1, Dawid Lewandowski1, Anna Olejnik1
1Faculty of Chemistry, Adam Mickiewicz University in Poznań, Umultowska 89B, Poznań 61-614, Poland.
International Journal of Pharmaceutics
|June 27, 2014
Abstract:
Ibuprofen (IBU) was chosen as a model drug to investigate the drug delivery rate. Mesoporous MCM-41 has been charged with ibuprofen (MCM-41_IBU). Calcium alginate was applied to encapsulate free drug and the mesoporous material. The system with double barrier demonstrated a slower release of IBU than free ibuprofen-loaded alginate beads and MCM-41_IBU. The IBU release from alginate matrix can be controlled by adjusting the free IBU/MCM-41_IBU ratio.