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Real-Time Monitoring of Aurora kinase A Activation using Conformational FRET Biosensors in Live Cells
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RNA stimulates Aurora B kinase activity during mitosis

Ashwini Jambhekar1, Amy B Emerman1, Caterina T H Schweidenback1

  • 1Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America; Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America.

Plos One
|June 27, 2014
PubMed
Summary

RNA regulates the mitotic kinase Aurora-B (AurB) to promote cell division. This study reveals a translation-independent mechanism where RNA binding stimulates AurB activity, crucial for proper spindle assembly and cell viability.

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