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Denervation and beta2-adrenoceptor-agonist administration on craniofacial bone density.
Australian Orthodontic Journal
|June 28, 2014
Summary
Intramuscular formoterol increased bone density in rat jaws and cheekbones. This effect may be linked to increased muscle mass from beta2-agonist use, impacting craniofacial bone structure.
Area of Science:
- Craniofacial biology
- Bone metabolism
- Pharmacology
Background:
- Beta2-agonists may negatively affect bone density.
- Surgical denervation and beta2-agonist injections have opposing effects on skeletal muscles.
Purpose of the Study:
- To investigate the impact of masseter muscle denervation, beta2-agonist (formoterol) injection, and their combination on craniofacial bone density in rats.
Main Methods:
- Four groups of Sprague-Dawley rats were used: sham, denervation, denervation + formoterol, and formoterol.
- CT examination and volumetric analysis of mineralized bone tissue were performed.
Main Results:
- Formoterol injection (alone or with denervation) increased maxillary bone density compared to sham and denervation groups.
- Formoterol also increased zygomatic bone density on the experimental side compared to the control side.
Conclusions:
- Intramuscular formoterol administration appears to bilaterally enhance bone mineral density in the maxilla and zygoma.
- This effect is likely secondary to increased muscle mass and strength associated with beta2-agonist administration.
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