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Prognostic value of matrix metalloproteinase 9 expression in patients with juvenile nasopharyngeal angiofibroma:
Xicai Sun1, Limin Guo1, Jingjing Wang1
1Department of Otolaryngology, Eye, Ear, Nose and Throat Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Objective:
Although JNA is a benign neoplasm histopathologically, it has a propensity for locally destructive growth and remains a higher postoperative recurrence rate. The aim of this study was to analyze the expression and localization of MMP-9 in JNA using tissue microarray to elucidate its correlation with clinicopathological features and recurrence.
Materials And Methods:
The expression of MMP-9 was assessed by immunohistochemistry in a tissue microarray from 70 patients with JNA and 10 control subjects. Correlation between the levels of MMP-9 expression and clinicopathologic variables, as well as tumor recurrence, were analyzed.
Results:
MMP-9 was detected in perivascular and extravascular less differentiated cells and stromal cells of patients with JNA but not in the matured vascular endothelial cells of these patients. The presence of MMP-9 expression in JNA was correlated with patient's age (p=0.001). Spearman correlation analysis suggested that high expression of MMP-9 in JNA had negative correlation with patient's age (r=-0.412, p<0.001). The recurrence rate in JNA patients with high MMP-9 expression was significantly higher than those with low MMP-9 expression (p=0.002). In multivariate and ROC curve analysis, MMP-9 was a good prognostic factor for tumor recurrence of JNA.
Conclusion:
Higher MMP-9 expression is a poor prognostic factor for patients with JNA who have been surgically treated.
Insights
High expression of matrix metalloproteinase-9 (MMP-9) in juvenile nasopharyngeal angiofibroma (JNA) indicates a higher risk of tumor recurrence after surgery. MMP-9 levels correlate with patient age and serve as a prognostic indicator for JNA.
Area of Science:
- Oncology
- Pathology
- Biochemistry
Background:
- Juvenile nasopharyngeal angiofibroma (JNA) is a benign tumor with aggressive local growth and high recurrence rates.
- Understanding molecular markers associated with JNA progression is crucial for predicting patient outcomes.
Purpose of the Study:
- To investigate the expression and localization of matrix metalloproteinase-9 (MMP-9) in JNA.
- To determine the correlation between MMP-9 expression and clinicopathological features, including tumor recurrence.
Main Methods:
- Immunohistochemistry was used to assess MMP-9 expression in JNA tissue microarrays from 70 patients and 10 controls.
- Statistical analyses, including Spearman correlation, multivariate analysis, and ROC curve analysis, were performed.
Main Results:
- MMP-9 was detected in JNA cells and stromal cells, but not in mature vascular endothelial cells.
- Higher MMP-9 expression correlated with a significantly higher recurrence rate in JNA patients.
- MMP-9 expression was negatively correlated with patient age.
Conclusions:
- Elevated MMP-9 expression is a significant poor prognostic factor for surgically treated JNA.
- MMP-9 serves as a valuable biomarker for predicting tumor recurrence in JNA.
