Calcium signaling in axon guidance
Related Experiment Video
Updated: Apr 27, 2026

Fluorescent Calcium Imaging and Subsequent In Situ Hybridization for Neuronal Precursor Characterization in Xenopus laevis
Published on: February 18, 2020
Daniel J Sutherland1, Zac Pujic1, Geoffrey J Goodhill2
1Queensland Brain Institute, The University of Queensland, St Lucia, QLD 4072, Australia.
Abstract:
Guidance of axons to their targets in the developing nervous system requires a myriad of downstream signaling molecules to coordinate growth cone movement. One of the most important of these is calcium, and over the past few years many new insights have been gained into the role of calcium in axon guidance. In this review we focus on mechanisms of calcium entry into the growth cone and its downstream effects on both growth cone motility and turning. We particularly highlight the role of calcium concentrations in determining attractive versus repulsive responses to graded guidance cues, and their role in guidance by the morphogen Wnt5a.
Related Concept Videos
Calmodulin-dependent Signaling
The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...
Feedback Regulation of Calcium Concentration
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...
Non-Canonical Wnt Signaling Pathways
Cytoskeletal Coordination in Cell Migration
Cell Polarization by Rho Proteins
Intracellular Signaling Affects Focal Adhesions
Some...

