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Updated: Apr 27, 2026
Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
Published on: January 22, 2018
Lack of any prognostic relationship between adiponectin receptor (Adipo R1/R2) expression for early/advanced stage
Talat Ayyildiz1, Enver Dolar, Nesrin Ugras
1Department of Gastroenterology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey E-mail : talatayy@gmail.com A.
Introduction:
Adiponectin (ApN) is a complement C1q-related protein, mainly secreted from adipose tissue, that signals through ApN receptor 1 (Adipo-R1) and ApN receptor 2 (Adipo-R2). Low serum ApN concentrations are associated with obesity-related malignancies. However, there are very few studies on any prognostic role of ApN receptors in gastric cancer.
Objectives:
The aim of this study is to investigate the relationship between AdipoR1/R2 expression and early/advanced stage gastric cancer in terms of clinicopathologic characteristics and survival.
Materials And Methods:
Eighteen patients with early and 39 with advanced stage gastric cancer who underwent surgical gastric resection were included in this study.
Results:
Adipo-R1 expression was low in 2 of the 18 patients with early stage gastric cancer (11.1%), while 4 had low Adipo-R2 expression (22.2%). In those with advanced stage gastric cancer, 7 of 39 had low Adipo-R1 expression (17.9%) and 16 had low Adipo-R2 expression (41%). Adipo-R2 expression was significantly higher (p=0.011) in moderately differentiated tumors when compared to well-differentiated tumors. While there was nearly a statistically significant relationship between TNM stage (T, tumor size; N, regional lymph node; M, whether distant metastases exist) and Adipo-R2 expression (p=0.054), there was no relationship between Adipo-R1/-R2 expression with tumor stage and survival.
Conclusion:
Adipo-R1/-R2 expression has no prognostic significance of in early/advanced stage gastric cancer.
