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Oxidative status parameters in children with urinary tract infection
Stanislava Petrovic1, Natasa Bogavac-Stanojevic, Jelena Kotur-Stevuljevic
1Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia.
Insights
Oxidative stress markers, total antioxidant status (TAS) and oxidative stress index (OSI), are sensitive to inflammation duration in children with urinary tract infections (UTI). These markers may help monitor disease severity.
Area of Science:
- Pediatric infectious diseases
- Biochemistry
- Nephrology
Background:
- Urinary tract infection (UTI) is a common pediatric bacterial infection.
- Oxidative status plays a role in UTI pathogenesis and complications.
- Understanding oxidative-antioxidant balance is crucial for managing pediatric UTI.
Purpose of the Study:
- To assess total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI) in children with UTI.
- To investigate the relationship between oxidative status parameters and inflammation persistence.
- To examine oxidative status changes in relation to acute kidney injury (AKI) development.
Main Methods:
- Serum analysis of TOS, TAS, OSI, C-reactive protein (CRP), urea, and creatinine in 50 pediatric UTI patients.
- Correlation of oxidative status parameters with inflammation duration and AKI development.
Main Results:
- Higher TAS and lower OSI values were observed in children with longer inflammation duration during UTI.
- No significant difference in basal oxidative status parameters was found concerning AKI development.
- OSI values reflected changes in the oxidative-antioxidant balance during UTI recovery.
Conclusions:
- TAS and OSI are sensitive indicators of oxidative stress in pediatric UTI, particularly concerning inflammation.
- OSI can detect simultaneous changes in TAS and TOS, reflecting oxidative-antioxidant balance shifts.
- Further research is warranted to explore the utility of TAS, TOS, and OSI in monitoring UTI severity in children.
Introduction:
Urinary tract infection (UTI) is one of the most common bacterial infectious diseases in children. The aim of this study was to determine the total prooxidant and antioxidant capacity of children with UTI, as well as changes of oxidative status parameters according to acute inflammation persistence and acute kidney injury (AKI) development.
Materials And Methods:
The patients enrolled in the study comprised 50 Caucasian children (median age was 6 months) with UTI. Total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), inflammation marker C-reactive protein (CRP) and renal function parameters urea and creatinine were analyzed in patient's serums.
Results:
According to duration of inflammation during UTI, TAS values were significantly higher (0.99 vs. 0.58 mmol/L, P = 0.017) and OSI values were significantly lower (0.032 vs. 0.041 AU, P = 0.037) in the subjects with longer duration of inflammation than in the subjects with shorter duration of inflammation. We did not find significant difference in basal values of oxidative status parameters according to AKI development.
Conclusion:
OSI values could detect the simultaneous change of TAS and TOS due to change in the oxidative-antioxidant balance during the recovery of children with UTI. TAS and OSI as markers of oxidative stress during UTI are sensitive to accompanying inflammatory condition. Further investigations are needed to evaluate whether TAS, TOS and OSI could be used to monitor disease severity in children with UTI.
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