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Related Experiment Video

Updated: Apr 27, 2026

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

Published on: November 13, 2016

GABA, resting-state connectivity and the developing brain.

Soo Hyun Kwon¹, Dustin Scheinost, Cheryl Lacadie

¹Department of Pediatrics, Yale School of Medicine, New Haven, Conn., USA.

|June 28, 2014

Summary

This summary is machine-generated.

Preterm infants show altered brain connectivity and lower GABA levels compared to full-term infants. These differences in gamma-aminobutyric acid (GABA) concentration are linked to brain functional connectivity.

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Cerebral Blood Flow-Based Resting State Functional Connectivity of the Human Brain using Optical Diffuse Correlation Spectroscopy

Cerebral Blood Flow-Based Resting State Functional Connectivity of the Human Brain using Optical Diffuse Correlation Spectroscopy

Published on: May 27, 2020

Area of Science:

Neuroscience
Developmental Neuroscience
Neonatal Brain Imaging

Background:

Gamma-aminobutyric acid (GABA) interneurons are crucial for establishing brain connectivity during development.
Preclinical studies highlight the role of GABA in initiating neural connections.

Purpose of the Study:

To compare GABA concentration and its association with functional connectivity in preterm versus term infants.
To investigate differences in brain connectivity and GABA levels at term-equivalent age.

Main Methods:

Utilized magnetic resonance spectroscopy (MRS) and functional magnetic resonance imaging (fMRI) in term-equivalent age infants.
Analyzed whole-brain functional connectivity using intrinsic connectivity distribution maps.
Measured GABA, glutamate, N-acetyl-aspartate (NAA), and choline concentrations via MRS.

Main Results:

Preterm infants exhibited lower right frontal GABA and glutamate concentrations compared to term controls.
A distinct relationship between GABA concentration and functional connectivity was observed in the right frontal lobe of preterm infants.
Preterm infants showed a positive correlation between GABA and connectivity, contrasting with a negative correlation in term controls.

Conclusions:

Regional GABA concentrations are associated with both normal and altered neonatal resting-state brain connectivity.
Findings suggest potential neurobiological differences in brain development between preterm and term infants related to GABA.