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Potent contractile effect of endothelin in isolated guinea-pig airways
C A Maggi1, R Patacchini, S Giuliani
1Pharmacology Department, A Menarini Pharmaceuticals, Florence, Italy.
European Journal of Pharmacology
|January 24, 1989
Abstract:
Endothelin produced a concentration-dependent (1 nM-0.3 microM) contraction of isolated guinea-pig airways (trachea and main bronchi). The response was unaffected by tetrodotoxin (1 microM) and slightly depressed by indomethacin (5 microM) but promptly abolished by isoprenaline (1 microM) or EDTA (3 mM). In the bronchi, the response to endothelin was enhanced by removal (rubbing) of the epithelium. The response of the trachea or bronchi to endothelin (0.3 microM) was unaffected by NiCl2 (0.1 mM) or omega conotoxin (0.1 microM) but was partially inhibited by nifedipine (1 microM).