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Updated: Apr 27, 2026

In Vivo Calcium Imaging of Lateral-line Hair Cells in Larval Zebrafish
Published on: November 28, 2018
Role of intracellular calcium stores in hair-cell ribbon synapse
Manuel Castellano-Muñoz1, Anthony J Ricci2
1Department of Otolaryngology, Stanford University School of Medicine Stanford, CA, USA.
Abstract:
Intracellular calcium stores control many neuronal functions such as excitability, gene expression, synaptic plasticity, and synaptic release. Although the existence of calcium stores along with calcium-induced calcium release (CICR) has been demonstrated in conventional and ribbon synapses, functional significance and the cellular mechanisms underlying this role remains unclear. This review summarizes recent experimental evidence identifying contribution of CICR to synaptic transmission and synaptic plasticity in the CNS, retina and inner ear. In addition, the potential role of CICR in the recruitment of vesicles to releasable pools in hair-cell ribbon synapses will be specifically discussed.
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